9nm3: Difference between revisions
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==Crystal structure of FBF-1 RBD+CT complexed with compact FBE RNA== | |||
<StructureSection load='9nm3' size='340' side='right'caption='[[9nm3]], [[Resolution|resolution]] 2.65Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9nm3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NM3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NM3 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nm3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nm3 OCA], [https://pdbe.org/9nm3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nm3 RCSB], [https://www.ebi.ac.uk/pdbsum/9nm3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nm3 ProSAT]</span></td></tr> | ||
[[Category: Hall | </table> | ||
[[Category: Qiu | == Function == | ||
[https://www.uniprot.org/uniprot/FBF1_CAEEL FBF1_CAEEL] RNA-binding protein that binds to the consensus sequence 5'-UGUGCCAUA-3' in mRNA 3'-UTRs (By similarity). Involved in the control of stem cells and sex determination in the C.elegans hermaphrodite germline (PubMed:9393998). May also play a role in the hermaphrodite germline proliferation and oogenesis (PubMed:15454534, PubMed:9393998). Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch (PubMed:15454534, PubMed:9393998). Negatively regulates gld-3 expression, possibly by directly binding to two sites within the 3'-UTR of gld-3 isoform b (PubMed:15454534, PubMed:9393998). In association with the cye-1/cdk-2 complex, negatively regulates gld-1 expression in the distal germline cells of the mitotic zone (PubMed:21455289). By binding to the 3'-UTR, represses phosphatase lip-1 expression in the distal part of the germline mitotic zone (PubMed:16319922). Suppresses germline tumor formation by preventing the dedifferentiation of secondary spermatocytes (PubMed:22820175).[UniProtKB:Q09312]<ref>PMID:15454534</ref> <ref>PMID:16319922</ref> <ref>PMID:21455289</ref> <ref>PMID:22820175</ref> <ref>PMID:9393998</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Caenorhabditis elegans]] | |||
[[Category: Large Structures]] | |||
[[Category: Hall TMT]] | |||
[[Category: Qiu C]] | |||
Latest revision as of 06:22, 20 August 2025
Crystal structure of FBF-1 RBD+CT complexed with compact FBE RNA
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