9u4l: Difference between revisions
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The entry | ==Fibril structure of human alphaA-crystallin with pathogenic mutation R116C== | ||
<StructureSection load='9u4l' size='340' side='right'caption='[[9u4l]], [[Resolution|resolution]] 3.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9u4l]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9U4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9U4L FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9u4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9u4l OCA], [https://pdbe.org/9u4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9u4l RCSB], [https://www.ebi.ac.uk/pdbsum/9u4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9u4l ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/CRYAA_HUMAN CRYAA_HUMAN] Early-onset lamellar cataract;Early-onset nuclear cataract;Total early-onset cataract;Cataract-microcornea syndrome;Early-onset anterior polar cataract. Alpha-crystallin A 1-172 is found at nearly twofold higher levels in diabetic lenses than in age-matched control lenses.<ref>PMID:12356833</ref> The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CRYAA_HUMAN CRYAA_HUMAN] Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.<ref>PMID:22120592</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Cao Q]] | |||
[[Category: Song M]] | |||
Latest revision as of 06:24, 20 August 2025
Fibril structure of human alphaA-crystallin with pathogenic mutation R116C
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