9hgm: Difference between revisions
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==Structure of human DNMT2 with bound allosteric inhibitor== | |||
<StructureSection load='9hgm' size='340' side='right'caption='[[9hgm]], [[Resolution|resolution]] 2.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9hgm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HGM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HGM FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IUL:4-ethyl-~{N}-[[1-[[(2~{R})-1-(1~{H}-indol-3-yl)-4-[[2-(methylamino)-2-oxidanylidene-ethyl]amino]-4-oxidanylidene-butan-2-yl]carbamoyl]cyclopropyl]methyl]benzamide'>A1IUL</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hgm OCA], [https://pdbe.org/9hgm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hgm RCSB], [https://www.ebi.ac.uk/pdbsum/9hgm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hgm ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TRDMT_HUMAN TRDMT_HUMAN] Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).<ref>PMID:16424344</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Kopp J]] | |||
[[Category: Schwan M]] | |||
[[Category: Sinning I]] | |||
Latest revision as of 07:14, 27 August 2025
Structure of human DNMT2 with bound allosteric inhibitor
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