9m1y: Difference between revisions

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'''Unreleased structure'''


The entry 9m1y is ON HOLD  until Paper Publication
==NMR Structure of Mouse Keratin 17 Tail Domain (G390 - R433) in solution==
 
<StructureSection load='9m1y' size='340' side='right'caption='[[9m1y]]' scene=''>
Authors: Yeom, J., Lee, C.H., Kim, J.H.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9m1y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9M1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9M1Y FirstGlance]. <br>
Description: NMR Structure of Mouse Keratin 17 Tail Domain (G390 -R433) in solution
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 17 models</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9m1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9m1y OCA], [https://pdbe.org/9m1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9m1y RCSB], [https://www.ebi.ac.uk/pdbsum/9m1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9m1y ProSAT]</span></td></tr>
[[Category: Yeom, J]]
</table>
[[Category: Kim, J.H]]
== Function ==
[[Category: Lee, C.H]]
[https://www.uniprot.org/uniprot/K1C17_MOUSE K1C17_MOUSE] Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (PubMed:14714564, PubMed:16702408). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (PubMed:16702408). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (PubMed:16710422). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (PubMed:20871598). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.<ref>PMID:14714564</ref> <ref>PMID:16702408</ref> <ref>PMID:16710422</ref> <ref>PMID:20871598</ref> <ref>PMID:9786956</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Kim JH]]
[[Category: Lee CH]]
[[Category: Yeom J]]
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