9mey: Difference between revisions
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The entry | ==Crystal structure of RIT1(GDP) bound to LZTR1(Kelch domain)== | ||
<StructureSection load='9mey' size='340' side='right'caption='[[9mey]], [[Resolution|resolution]] 2.95Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9mey]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MEY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MEY FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mey OCA], [https://pdbe.org/9mey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mey RCSB], [https://www.ebi.ac.uk/pdbsum/9mey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mey ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/RIT1_HUMAN RIT1_HUMAN] Noonan syndrome. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RIT1_HUMAN RIT1_HUMAN] Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation.<ref>PMID:15632082</ref> <ref>PMID:23791108</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Bonsor DA]] | |||
[[Category: Dharmaiah S]] | |||
[[Category: Simanshu DK]] | |||
Latest revision as of 04:13, 14 September 2025
Crystal structure of RIT1(GDP) bound to LZTR1(Kelch domain)
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