9vix: Difference between revisions
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==human alpha 7 nicotinic acetylcholine receptor L278A mutant in complex with L-nicotine (desensitized state)== | |||
<StructureSection load='9vix' size='340' side='right'caption='[[9vix]], [[Resolution|resolution]] 3.06Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9vix]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9VIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9VIX FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.06Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NCT:(S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE'>NCT</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9vix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9vix OCA], [https://pdbe.org/9vix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9vix RCSB], [https://www.ebi.ac.uk/pdbsum/9vix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9vix ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/ACHA7_HUMAN ACHA7_HUMAN] 15q13.3 microdeletion syndrome. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ACHA7_HUMAN ACHA7_HUMAN] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chen H]] | |||
[[Category: Liu S]] | |||
[[Category: Tian C]] | |||
Latest revision as of 04:21, 14 September 2025
human alpha 7 nicotinic acetylcholine receptor L278A mutant in complex with L-nicotine (desensitized state)
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