9do9: Difference between revisions

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'''Unreleased structure'''


The entry 9do9 is ON HOLD  until Paper Publication
==Membrane-bound OlyA/PlyB (Hinge-Lock) prepore focused refinement==
 
<StructureSection load='9do9' size='340' side='right'caption='[[9do9]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9do9]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Pleurotus_ostreatus Pleurotus ostreatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DO9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DO9 FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.91&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1A8R:(4S,7S)-4-hydroxy-7-[(1R,2E)-1-hydroxyhexadec-2-en-1-yl]-N,N,N-trimethyl-4,9-dioxo-3,5-dioxa-8-aza-4lambda~5~-phosphahexacos-17-en-1-aminium'>A1A8R</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9do9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9do9 OCA], [https://pdbe.org/9do9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9do9 RCSB], [https://www.ebi.ac.uk/pdbsum/9do9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9do9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/OLYA6_PLEOS OLYA6_PLEOS] Has hemolytic activity against bovine erythrocytes at nanomolar concentrations in vitro. Promotes active pleurotolysin B (PlyB)-dependent permeabilization of membranes rich in cholesterol and sphingomyelin. May play an important role in the initial phase of fungal fruiting.<ref>PMID:12020804</ref> <ref>PMID:23806422</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pleurotus ostreatus]]
[[Category: Chen Z]]
[[Category: Han Y]]
[[Category: Li Y]]
[[Category: Radhakrishnan A]]
[[Category: Smothers J]]
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