9vg3: Difference between revisions

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'''Unreleased structure'''


The entry 9vg3 is ON HOLD  until Paper Publication
==SIRT2 structure in complex with H3K18myr peptide: pre NAD binding state==
 
<StructureSection load='9vg3' size='340' side='right'caption='[[9vg3]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
Authors: Zhang, N., Hao, Q.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9vg3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9VG3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9VG3 FirstGlance]. <br>
Description: SIRT2 structure in complex with H3K18myr peptide: pre NAD binding state
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Zhang, N]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9vg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9vg3 OCA], [https://pdbe.org/9vg3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9vg3 RCSB], [https://www.ebi.ac.uk/pdbsum/9vg3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9vg3 ProSAT]</span></td></tr>
[[Category: Hao, Q]]
</table>
== Function ==
[https://www.uniprot.org/uniprot/SIR2_HUMAN SIR2_HUMAN] NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA.<ref>PMID:12620231</ref> <ref>PMID:12697818</ref> <ref>PMID:21081649</ref> <ref>PMID:21726808</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Hao Q]]
[[Category: Zhang N]]
Retrieved from "https://proteopedia.org/9vg3"