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ISSN 2310-6301 As life is more than 2D, Proteopedia helps to bridge the gap between 3D structure & function of biomacromolecules Proteopedia presents this information in a user-friendly way as a collaborative & free 3D-encyclopedia of proteins & other biomolecules.
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How to add content to Proteopedia Video Guides Who knows ... Mutations in Coronavirus Spike Protein by Eric Martz Black spots are mutations of concern in SARS-CoV-2 spike protein reported by UK scientists in December, 2020. RNA viruses mutate quickly so mutations are expected. These mutations may speed up contagion, but are unlikely to cause more severe COVID-19 and unlikely to reduce vaccine effectiveness. ACE2 binding residues. Animation shows priming via cleavage by furin. >>> Visit this page >>>	About Interactive 3D Complements - I3DCs List of I3DCs How to get an I3DC for your paper Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases. IB Tomasic, MC Metcalf, AI Guce, NE Clark, SC Garman. J. Biol. Chem. 2010 doi: 10.1074/jbc.M110.118588 The human lysosomal enzymes α-galactosidase and α-N-acetylgalactosaminidase share 46% amino acid sequence identity and have similar folds. Using a rational protein engineering approach, we interconverted the enzymatic specificity of α-GAL and α-NAGAL. The engineered α-GAL retains the antigenicity but has acquired the enzymatic specificity of α-NAGAL. Conversely, the engineered α-NAGAL retains the antigenicity but has acquired the enzymatic specificity of the α-GAL enzyme. Comparison of the crystal structures of the designed enzyme to the wild-type enzymes shows that active sites superimpose well, indicating success of the rational design. The designed enzymes might be useful as non-immunogenic alternatives in enzyme replacement therapy for treatment of lysosomal storage disorders such as Fabry disease. >>> Visit this I3DC complement >>>	Teaching strategies using Proteopedia Examples of pages for teaching How to add content to Proteopedia Make Your Own Electrostatic Potential Maps Positive (+) and Negative (-) charges on the surface of a protein molecule play crucial roles in its interactions with other molecules, and hence in its functions. Electrostatic potential maps coloring the surface of a protein molecule are a popular way to visualize the distribution of surface charges. Easy to use free software is available to to create these surface maps. Above is an integral membrane potassium channel protein. One of its 4 identical chains is removed so you can see the Negative (-) protein surface contacting the 3 K+ ions. >>> See Examples and Get Instructions >>>
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