9jna: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9jna is ~~ON HOLD until Paper Publication~~

==Crystal Structure of SME-1 E166A mutant in complex with Meropenem==

~~Authors~~: ~~Dhankhar~~, K., ~~Hazra~~, S.

== Structural highlights ==

<table><tr><td colspan='2'>[[9jna]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JNA OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9JNA FirstGlance].

~~Description~~: ~~Crystal Structure~~ of ~~SME~~-~~1 E166A mutant in complex with Meropenem~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DWZ:(2S,3R,4S)-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-2-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-METHYL-3,4-DIHYDRO-2H-PYRROLE-5-CARBOXYLIC+ACID'>DWZ</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>

[[Category: ~~Hazra, S~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9jna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jna OCA], [https://pdbe.org/9jna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jna RCSB], [https://www.ebi.ac.uk/pdbsum/9jna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jna ProSAT]</td></tr>

[[Category: Dhankhar, K]]

</table>

== Function ==

[https://www.uniprot.org/uniprot/BLAS1_SERMA BLAS1_SERMA] Class A beta-lactamase which confers resistance to the beta-lactam antibiotics, including penicillins, some cephalosporins and carbapenems, to JM109 strain E.coli (PubMed:11807251, PubMed:8092824). Acts via hydrolysis of the beta-lactam ring (PubMed:11036019, PubMed:8092824). Has penicillin-, cephalosporin- and carbapenem-hydrolyzing activities (PubMed:11036019).<ref>PMID:11036019</ref> <ref>PMID:11807251</ref> <ref>PMID:8092824</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Serratia marcescens]]

[[Category: Dhankhar K]]

[[Category: Hazra S]]

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-'''Unreleased structure'''
-The entry 9jna is ON HOLD  until Paper Publication
+==Crystal Structure of SME-1 E166A mutant in complex with Meropenem==
+<StructureSection load='9jna' size='340' side='right'caption='[[9jna]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-Authors: Dhankhar, K., Hazra, S.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9jna]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JNA FirstGlance]. <br>
-Description: Crystal Structure of SME-1 E166A mutant in complex with Meropenem
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DWZ:(2S,3R,4S)-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-2-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-METHYL-3,4-DIHYDRO-2H-PYRROLE-5-CARBOXYLIC+ACID'>DWZ</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-[[Category: Hazra, S]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jna OCA], [https://pdbe.org/9jna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jna RCSB], [https://www.ebi.ac.uk/pdbsum/9jna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jna ProSAT]</span></td></tr>
-[[Category: Dhankhar, K]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/BLAS1_SERMA BLAS1_SERMA] Class A beta-lactamase which confers resistance to the beta-lactam antibiotics, including penicillins, some cephalosporins and carbapenems, to JM109 strain E.coli (PubMed:11807251, PubMed:8092824). Acts via hydrolysis of the beta-lactam ring (PubMed:11036019, PubMed:8092824). Has penicillin-, cephalosporin- and carbapenem-hydrolyzing activities (PubMed:11036019).<ref>PMID:11036019</ref> <ref>PMID:11807251</ref> <ref>PMID:8092824</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Serratia marcescens]]
+[[Category: Dhankhar K]]
+[[Category: Hazra S]]