9pfo: Difference between revisions
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==Structure of POU2F3 POU domains bound to coactivator OCA-T2 and DNA (2.1 angstrom resolution)== | |||
<StructureSection load='9pfo' size='340' side='right'caption='[[9pfo]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9pfo]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9PFO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9PFO FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9pfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9pfo OCA], [https://pdbe.org/9pfo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9pfo RCSB], [https://www.ebi.ac.uk/pdbsum/9pfo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9pfo ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PO2F3_HUMAN PO2F3_HUMAN] Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and regulates cell type-specific differentiation pathways. Involved in the regulation of keratinocytes differentiation (PubMed:11329378). The POU2F3-POU2AF2/POU2AF3 complex drives the expression of tuft-cell-specific genes, a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues (PubMed:35576971).<ref>PMID:11329378</ref> <ref>PMID:35576971</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Alpsoy A]] | |||
[[Category: Ipsaro JJ]] | |||
[[Category: Joshua-Tor L]] | |||
[[Category: Vakoc CR]] | |||
Latest revision as of 05:59, 1 October 2025
Structure of POU2F3 POU domains bound to coactivator OCA-T2 and DNA (2.1 angstrom resolution)
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