6swm: Difference between revisions

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<StructureSection load='6swm' size='340' side='right'caption='[[6swm]], [[Resolution|resolution]] 2.77&Aring;' scene=''>
<StructureSection load='6swm' size='340' side='right'caption='[[6swm]], [[Resolution|resolution]] 2.77&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6swm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SWM FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SWM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.77&#8491;</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.77&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LVW:(2~{R})-1-prop-2-enoxy-3-selanyl-propan-2-ol'>LVW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LVW:(2~{R})-1-prop-2-enoxy-3-selanyl-propan-2-ol'>LVW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6swm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6swm OCA], [https://pdbe.org/6swm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6swm RCSB], [https://www.ebi.ac.uk/pdbsum/6swm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6swm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6swm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6swm OCA], [https://pdbe.org/6swm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6swm RCSB], [https://www.ebi.ac.uk/pdbsum/6swm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6swm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAH1_HUMAN CAH1_HUMAN] Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.<ref>PMID:10550681</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Stable aryl selenols were obtained through a convenient procedure. Selenols represent a new chemotype acting as carbonic anhydrase inhibitors (CAIs), inhibiting four human isoforms, CAs I, II, VII and the tumor-associated CA IX. X-ray crystallographic, physical and computational studies provided insights into the binding mode of this conceptually new class of CAIs.
Selenols: a new class of carbonic anhydrase inhibitors.,Angeli A, Tanini D, Nocentini A, Capperucci A, Ferraroni M, Gratteri P, Supuran CT Chem Commun (Camb). 2018 Dec 18. doi: 10.1039/c8cc08562e. PMID:30560259<ref>PMID:30560259</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6swm" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Carbonic anhydrase 3D structures|Carbonic anhydrase 3D structures]]
*[[Carbonic anhydrase 3D structures|Carbonic anhydrase 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Angeli A]]
[[Category: Angeli A]]
[[Category: Ferraroni M]]
[[Category: Ferraroni M]]

Latest revision as of 06:25, 1 October 2025

selenol bound carbonic anhydrase I

6swm, resolution 2.77Å

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