8s7k: Difference between revisions
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==M. tuberculosis gyrase holocomplex with 150 bp DNA and gepotidacin== | |||
<StructureSection load='8s7k' size='340' side='right'caption='[[8s7k]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8s7k]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8S7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8S7K FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JHN:(3~{R})-3-[[4-(3,4-dihydro-2~{H}-pyrano[2,3-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.0^{4,12}]dodeca-6,8(12),9-triene-5,11-dione'>JHN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8s7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8s7k OCA], [https://pdbe.org/8s7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8s7k RCSB], [https://www.ebi.ac.uk/pdbsum/8s7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8s7k ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GYRA_MYCTU GYRA_MYCTU] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mycobacterium tuberculosis]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Gubellini F]] | |||
[[Category: Mechaly A]] | |||
[[Category: Petrella S]] | |||
[[Category: Willand N]] | |||
[[Category: Yab E]] | |||
Latest revision as of 07:15, 8 October 2025
M. tuberculosis gyrase holocomplex with 150 bp DNA and gepotidacin
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