9du1: Difference between revisions
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==Co-crystal structure of the ternary complex of human FKBP12, BRD9 bromo domain and Compound 1== | |||
<StructureSection load='9du1' size='340' side='right'caption='[[9du1]], [[Resolution|resolution]] 2.01Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9du1]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DU1 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BB8:4-[4-[cyclopropyl-[(1-methylpyrazol-4-yl)methyl]amino]-6-[[1-[(2~{R})-2-[[(2~{S})-1-(3,3-dimethyl-2-oxidanylidene-pentanoyl)piperidin-2-yl]carbonylamino]-4-(4-methoxyphenyl)butanoyl]piperidin-4-yl]amino]-1,3,5-triazin-2-yl]-~{N}-ethyl-piperazine-1-carboxamide'>A1BB8</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9du1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9du1 OCA], [https://pdbe.org/9du1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9du1 RCSB], [https://www.ebi.ac.uk/pdbsum/9du1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9du1 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>PMID:9233797</ref> <ref>PMID:16720724</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Romanowski MJ]] | |||
[[Category: Viscomi JS]] | |||
Latest revision as of 07:18, 8 October 2025
Co-crystal structure of the ternary complex of human FKBP12, BRD9 bromo domain and Compound 1
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