9gwj: Difference between revisions
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==Crystal structure of CINP-c1orf109 complex== | |||
<StructureSection load='9gwj' size='340' side='right'caption='[[9gwj]], [[Resolution|resolution]] 3.69Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9gwj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GWJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GWJ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.69Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gwj OCA], [https://pdbe.org/9gwj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gwj RCSB], [https://www.ebi.ac.uk/pdbsum/9gwj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gwj ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/AIRIM_HUMAN AIRIM_HUMAN] Part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity (PubMed:38554706). Involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024).<ref>PMID:35354024</ref> <ref>PMID:38554706</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Masternak M]] | |||
[[Category: Montoya G]] | |||
[[Category: Weisser M]] | |||
Latest revision as of 07:21, 8 October 2025
Crystal structure of CINP-c1orf109 complex
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