9jt6: Difference between revisions

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'''Unreleased structure'''


The entry 9jt6 is ON HOLD  until Paper Publication
==Crystal structure of Aldo-keto reductase 1C3 complexed with compound S30-1045==
 
<StructureSection load='9jt6' size='340' side='right'caption='[[9jt6]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
Authors: Jiang, J., Sun, H., Fang, P.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9jt6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JT6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JT6 FirstGlance]. <br>
Description: Crystal structure of Aldo-keto reductase 1C3 complexed with compound S30-1045
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EC4:4-[[(7-fluoranyl-2~{H}-chromen-3-yl)carbonyl-methyl-amino]methyl]benzoic+acid'>A1EC4</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
[[Category: Jiang, J]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jt6 OCA], [https://pdbe.org/9jt6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jt6 RCSB], [https://www.ebi.ac.uk/pdbsum/9jt6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jt6 ProSAT]</span></td></tr>
[[Category: Sun, H]]
</table>
[[Category: Fang, P]]
== Function ==
[https://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Fang P]]
[[Category: Jiang J]]
[[Category: Sun H]]
Retrieved from "https://proteopedia.org/9jt6"