9v44: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Coupling of polymerase-nucleoprotein-RNA in an influenza virus mini ribonucleoprotein complex== | |||
<StructureSection load='9v44' size='340' side='right'caption='[[9v44]], [[Resolution|resolution]] 2.97Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9v44]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Victoria/3/1975(H3N2)) Influenza A virus (A/Victoria/3/1975(H3N2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9V44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9V44 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.97Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9v44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9v44 OCA], [https://pdbe.org/9v44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9v44 RCSB], [https://www.ebi.ac.uk/pdbsum/9v44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9v44 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/H9XIJ2_I75A3 H9XIJ2_I75A3] Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.[HAMAP-Rule:MF_04063] | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Kang H]] | ||
[[Category: | [[Category: Li M]] | ||
[[Category: Lin Y]] | |||
[[Category: Liu Y]] | |||
[[Category: Lou Z]] | |||
[[Category: Rao Z]] | |||
[[Category: Yang Y]] | |||
[[Category: Zhang L]] | |||
Latest revision as of 07:37, 8 October 2025
Coupling of polymerase-nucleoprotein-RNA in an influenza virus mini ribonucleoprotein complex
| ||||||||||||
