9i9j: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 9i9j is ~~ON HOLD until Paper Publication~~

==Cryo-EM structure of CAK-CDK2 (determined in the presence of ADP-nitrate)==

~~Authors~~: ~~Cushing~~, V.I., ~~Greber, B~~.J., ~~McGeoch~~, A.J.S., ~~Feng~~, J.

== Structural highlights ==

<table><tr><td colspan='2'>[[9i9j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9I9J OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9I9J FirstGlance].

~~Description~~: ~~Cryo~~-~~EM structure of~~ CAK-CDK2 ~~(determined in~~ the ~~presence~~ of ~~ADP~~-~~nitrate~~)

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

[[Category: ~~Greber, B.J~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9i9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9i9j OCA], [https://pdbe.org/9i9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9i9j RCSB], [https://www.ebi.ac.uk/pdbsum/9i9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9i9j ProSAT]</td></tr>

[[Category: Feng, J]]

</table>

[[Category: ~~Mcgeoch, A.J.S~~]]

== Function ==

[[Category: ~~Cushing, V.I~~]]

[https://www.uniprot.org/uniprot/CCNH_HUMAN CCNH_HUMAN] Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.<ref>PMID:7533895</ref> <ref>PMID:10024882</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Cushing VI]]

[[Category: Feng J]]

[[Category: Greber BJ]]

[[Category: McGeoch AJS]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9i9j is ON HOLD  until Paper Publication
+==Cryo-EM structure of CAK-CDK2 (determined in the presence of ADP-nitrate)==
+<StructureSection load='9i9j' size='340' side='right'caption='[[9i9j]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
-Authors: Cushing, V.I., Greber, B.J., McGeoch, A.J.S., Feng, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9i9j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9I9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9I9J FirstGlance]. <br>
-Description: Cryo-EM structure of CAK-CDK2 (determined in the presence of ADP-nitrate)
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Greber, B.J]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9i9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9i9j OCA], [https://pdbe.org/9i9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9i9j RCSB], [https://www.ebi.ac.uk/pdbsum/9i9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9i9j ProSAT]</span></td></tr>
-[[Category: Feng, J]]
+</table>
-[[Category: Mcgeoch, A.J.S]]
+== Function ==
-[[Category: Cushing, V.I]]
+[https://www.uniprot.org/uniprot/CCNH_HUMAN CCNH_HUMAN] Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.<ref>PMID:7533895</ref> <ref>PMID:10024882</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Cushing VI]]
+[[Category: Feng J]]
+[[Category: Greber BJ]]
+[[Category: McGeoch AJS]]