9i9k: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 9i9k is ~~ON HOLD until Paper Publication~~

==Cryo-EM structure of CAK-CDK2 (determined in the presence of ADP-AlFx)==

~~Authors~~: ~~Cushing~~, V.I., ~~Greber, B~~.J., ~~McGeoch~~, A.J.S., ~~Feng~~, J.

== Structural highlights ==

<table><tr><td colspan='2'>[[9i9k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9I9K OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9I9K FirstGlance].

~~Description~~: ~~Cryo~~-~~EM structure of~~ CAK-CDK2 ~~(determined in~~ the ~~presence~~ of ~~ADP~~-~~AlFx~~)

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.4Å</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

[[Category: ~~Mcgeoch, A.J.S~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9i9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9i9k OCA], [https://pdbe.org/9i9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9i9k RCSB], [https://www.ebi.ac.uk/pdbsum/9i9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9i9k ProSAT]</td></tr>

[[Category: Cushing~~, V.I~~]]

</table>

[[Category: Feng, J]]

== Function ==

[[Category: Greber~~, B.J~~]]

[https://www.uniprot.org/uniprot/MAT1_HUMAN MAT1_HUMAN] Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.<ref>PMID:10024882</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Cushing VI]]

[[Category: Feng J]]

[[Category: Greber BJ]]

[[Category: McGeoch AJS]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9i9k is ON HOLD  until Paper Publication
+==Cryo-EM structure of CAK-CDK2 (determined in the presence of ADP-AlFx)==
+<StructureSection load='9i9k' size='340' side='right'caption='[[9i9k]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-Authors: Cushing, V.I., Greber, B.J., McGeoch, A.J.S., Feng, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9i9k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9I9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9I9K FirstGlance]. <br>
-Description: Cryo-EM structure of CAK-CDK2 (determined in the presence of ADP-AlFx)
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Mcgeoch, A.J.S]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9i9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9i9k OCA], [https://pdbe.org/9i9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9i9k RCSB], [https://www.ebi.ac.uk/pdbsum/9i9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9i9k ProSAT]</span></td></tr>
-[[Category: Cushing, V.I]]
+</table>
-[[Category: Feng, J]]
+== Function ==
-[[Category: Greber, B.J]]
+[https://www.uniprot.org/uniprot/MAT1_HUMAN MAT1_HUMAN] Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.<ref>PMID:10024882</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Cushing VI]]
+[[Category: Feng J]]
+[[Category: Greber BJ]]
+[[Category: McGeoch AJS]]