9jqz: Difference between revisions
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==Structural Insights into Selective Antagonism Grapiprant and EP4 Prostaglandin Receptor== | |||
<StructureSection load='9jqz' size='340' side='right'caption='[[9jqz]], [[Resolution|resolution]] 2.65Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9jqz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JQZ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.65Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1ECR:1-[2-[4-(2-ethyl-4,6-dimethyl-imidazo[4,5-c]pyridin-1-yl)phenyl]ethyl]-3-(4-methylphenyl)sulfonyl-urea'>A1ECR</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jqz OCA], [https://pdbe.org/9jqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jqz RCSB], [https://www.ebi.ac.uk/pdbsum/9jqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jqz ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PE2R4_HUMAN PE2R4_HUMAN] Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Wu CR]] | |||
[[Category: Wu YL]] | |||
[[Category: Xu EH]] | |||
[[Category: Xu JY]] | |||
[[Category: Zhang H]] | |||
Latest revision as of 09:11, 22 October 2025
Structural Insights into Selective Antagonism Grapiprant and EP4 Prostaglandin Receptor
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