9l2r: Difference between revisions

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'''Unreleased structure'''


The entry 9l2r is ON HOLD  until 2026-12-17
==Crystal structure of the SeMet-derived C-terminal of viral responsive protein 15 (PmVRP15) from black tiger shrimp Penaeus monodon==
<StructureSection load='9l2r' size='340' side='right'caption='[[9l2r]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9l2r]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Penaeus_monodon Penaeus monodon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9L2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9L2R FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9l2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9l2r OCA], [https://pdbe.org/9l2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9l2r RCSB], [https://www.ebi.ac.uk/pdbsum/9l2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9l2r ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/X2FU51_PENMO X2FU51_PENMO]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
White spot syndrome virus (WSSV) is a major serious threat to black tiger shrimp farming. WSSV infection induces a host protein, viral responsive protein 15 (VRP15), for viral assembly and nuclear egress. Here, we showed that the C-terminal tail of VRP15 (VRP15-C) interacts directly with the viral nucleocapsid tegument protein WSV399. The crystal structure of VRP15-C was determined at 1.5 A. The structure showed that VRP15-C forms a dimer by forming an alpha-helix bundle structure and that the dimer further interacts with adjacent dimers to form a tetramer and a higher oligomer by intermolecular helix-helix interactions. The ability to form oligomeric forms may contribute to assembly of viral proteins to form a nucleocapsid of WSSV.


Authors:  
Structure of the C-terminal of Viral Responsive Protein 15 (VRP15): A Key Protein During White Spot Syndrome Virus (WSSV) Infection.,Laohawutthichai P, Kim SY, Chek MF, Jatuyosporn T, Tassanakajon A, Krusong K, Hakoshima T J Mol Biol. 2025 Oct 1;437(19):169329. doi: 10.1016/j.jmb.2025.169329. Epub 2025 , Jul 8. PMID:40639753<ref>PMID:40639753</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 9l2r" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Penaeus monodon]]
[[Category: Chek MF]]
[[Category: Hakoshima T]]
[[Category: Kim S-Y]]
[[Category: Krusong K]]
[[Category: Laohawutthichai P]]
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