9l2w: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal structure of the C-terminal of viral responsive protein 15 (PmVRP15) from black tiger shrimp Penaeus monodon== | |||
<StructureSection load='9l2w' size='340' side='right'caption='[[9l2w]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9l2w]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Penaeus_monodon Penaeus monodon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9L2W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9L2W FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9l2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9l2w OCA], [https://pdbe.org/9l2w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9l2w RCSB], [https://www.ebi.ac.uk/pdbsum/9l2w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9l2w ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/X2FU51_PENMO X2FU51_PENMO] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
White spot syndrome virus (WSSV) is a major serious threat to black tiger shrimp farming. WSSV infection induces a host protein, viral responsive protein 15 (VRP15), for viral assembly and nuclear egress. Here, we showed that the C-terminal tail of VRP15 (VRP15-C) interacts directly with the viral nucleocapsid tegument protein WSV399. The crystal structure of VRP15-C was determined at 1.5 A. The structure showed that VRP15-C forms a dimer by forming an alpha-helix bundle structure and that the dimer further interacts with adjacent dimers to form a tetramer and a higher oligomer by intermolecular helix-helix interactions. The ability to form oligomeric forms may contribute to assembly of viral proteins to form a nucleocapsid of WSSV. | |||
Structure of the C-terminal of Viral Responsive Protein 15 (VRP15): A Key Protein During White Spot Syndrome Virus (WSSV) Infection.,Laohawutthichai P, Kim SY, Chek MF, Jatuyosporn T, Tassanakajon A, Krusong K, Hakoshima T J Mol Biol. 2025 Oct 1;437(19):169329. doi: 10.1016/j.jmb.2025.169329. Epub 2025 , Jul 8. PMID:40639753<ref>PMID:40639753</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 9l2w" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Penaeus monodon]] | |||
[[Category: Chek MF]] | |||
[[Category: Hakoshima T]] | |||
[[Category: Kim S-Y]] | |||
[[Category: Krusong K]] | |||
[[Category: Laohawutthichai P]] | |||
Latest revision as of 09:16, 22 October 2025
Crystal structure of the C-terminal of viral responsive protein 15 (PmVRP15) from black tiger shrimp Penaeus monodon
| ||||||||||||
