9swj: Difference between revisions
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==Human ADP-forming succinyl-CoA ligase complex SUCLG1-SUCLA2 bound to coenzyme A== | |||
<StructureSection load='9swj' size='340' side='right'caption='[[9swj]], [[Resolution|resolution]] 3.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9swj]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9SWJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9SWJ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9swj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9swj OCA], [https://pdbe.org/9swj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9swj RCSB], [https://www.ebi.ac.uk/pdbsum/9swj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9swj ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/SUCA_HUMAN SUCA_HUMAN] Fatal infantile lactic acidosis with methylmalonic aciduria. The disease is caused by mutations affecting the gene represented in this entry. | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/SUCA_HUMAN SUCA_HUMAN] Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.[HAMAP-Rule:MF_03222] | ||
[[Category: | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Bailey HJ]] | |||
[[Category: Burgess-Brown N]] | |||
[[Category: McCorvie TJ]] | |||
[[Category: Rembeza E]] | |||
[[Category: Shrestha L]] | |||
[[Category: Strain-Damerell C]] | |||
[[Category: Yue WW]] | |||
Latest revision as of 09:24, 22 October 2025
Human ADP-forming succinyl-CoA ligase complex SUCLG1-SUCLA2 bound to coenzyme A
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