9e39: Difference between revisions
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==Gag CA-SP1 (T8I) immature lattice bound with Bevirimat from enveloped virus like particles== | |||
<StructureSection load='9e39' size='340' side='right'caption='[[9e39]], [[Resolution|resolution]] 2.71Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9e39]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/HIV-1_M:B_HXB2R HIV-1 M:B_HXB2R]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9E39 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9E39 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.71Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2I4:(1~{R},3~{a}~{S},5~{a}~{R},5~{b}~{R},7~{a}~{R},9~{S},11~{a}~{R},11~{b}~{R},13~{a}~{R},13~{b}~{R})-9-(3,3-dimethyl-4-oxidanyl-4-oxidanylidene-butanoyl)oxy-5~{a},5~{b},8,8,11~{a}-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7~{a},9,10,11,11~{b},12,13,13~{a},13~{b}-hexadecahydrocyclopenta[a]chrysene-3~{a}-carboxylic+acid'>2I4</scene>, <scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9e39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9e39 OCA], [https://pdbe.org/9e39 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9e39 RCSB], [https://www.ebi.ac.uk/pdbsum/9e39 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9e39 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GAG_HV1H2 GAG_HV1H2] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: HIV-1 M:B_HXB2R]] | |||
[[Category: Large Structures]] | |||
[[Category: Meuser ME]] | |||
[[Category: Wu C]] | |||
[[Category: Xiong Y]] | |||
Revision as of 07:09, 29 October 2025
Gag CA-SP1 (T8I) immature lattice bound with Bevirimat from enveloped virus like particles
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