9mmd: Difference between revisions
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==[T:Ag+/Hg2+:T--(pH9.5-pH11; 21s)] Metal-mediated DNA base pair in tensegrity triangle grown at pH 9.5 and soaked in pH 11 with Ag+ and Hg2+ for 21s== | |||
<StructureSection load='9mmd' size='340' side='right'caption='[[9mmd]], [[Resolution|resolution]] 5.03Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9mmd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MMD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MMD FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 5.03Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AG:SILVER+ION'>AG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mmd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mmd OCA], [https://pdbe.org/9mmd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mmd RCSB], [https://www.ebi.ac.uk/pdbsum/9mmd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mmd ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The rational design of molecular electronics remains a grand challenge of materials science. DNA nanotechnology has offered unmatched control over molecular geometry, but direct electronic functionalization is a challenge. Here a generalized method is presented for tuning the local band structure of DNA using transmetalation in metal-mediated base pairs (mmDNA). A method is developed for time-resolved X-ray diffraction using self-assembling DNA crystals to establish the exchange of Ag(+) and Hg(2+) in T:T base pairs driven by pH exchange. Transmetalation is tracked over six reaction phases as crystal pH is changed from pH 8.0 to 11.0, and vice versa. A detailed computational analysis of the electronic configuration and transmission in the ensuing crystal structures is then performed. This findings reveal a high conductance contrast in the lowest unoccupied molecular orbitals (LUMO) as a result of metalation. The ability to exchange single transition metal ions as a result of environmental stimuli heralds a means of modulating the conductance of DNA-based molecular electronics. In this way, both theoretical and experimental basis are established by which mmDNA can be leveraged to build rewritable memory devices and nanoelectronics. | |||
Transmetalation for DNA-Based Molecular Electronics.,De A, Lu B, Ohayon YP, Woloszyn K, Livernois W, Perren L, Yang CF, Mao C, Botana AS, Hihath J, Canary JW, Sha R, Anantram MP, Vecchioni S Small. 2025 Jun;21(25):e2411518. doi: 10.1002/smll.202411518. Epub 2025 May 13. PMID:40364470<ref>PMID:40364470</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: Lu | <div class="pdbe-citations 9mmd" style="background-color:#fffaf0;"></div> | ||
[[Category: Vecchioni | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Lu B]] | |||
[[Category: Vecchioni S]] | |||
