9nyz: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9nyz is ~~ON HOLD until Paper Publication~~

==Crystal structure of DCKA/glutamate-bound GluN1/GluN2A agonist binding domains with UCM-101==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9nyz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NYZ OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9NYZ FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1B7E:N-(cyclohexylmethyl)-2-[(5-{[(1R)-1-phenylpropyl]amino}-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide'>A1B7E</scene>, <scene name='pdbligand=DK1:5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC+ACID'>DK1</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9nyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nyz OCA], [https://pdbe.org/9nyz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nyz RCSB], [https://www.ebi.ac.uk/pdbsum/9nyz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nyz ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/NMDZ1_RAT NMDZ1_RAT] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.<ref>PMID:15996549</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Rattus norvegicus]]

[[Category: Hansen KB]]

[[Category: Lotti JS]]

[[Category: McClelland LJ]]

[[Category: Syrenne JT]]

[[Category: Yates-Hansen CK]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9nyz is ON HOLD  until Paper Publication
+==Crystal structure of DCKA/glutamate-bound GluN1/GluN2A agonist binding domains with UCM-101==
+<StructureSection load='9nyz' size='340' side='right'caption='[[9nyz]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9nyz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NYZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NYZ FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1B7E:N-(cyclohexylmethyl)-2-[(5-{[(1R)-1-phenylpropyl]amino}-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide'>A1B7E</scene>, <scene name='pdbligand=DK1:5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC+ACID'>DK1</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nyz OCA], [https://pdbe.org/9nyz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nyz RCSB], [https://www.ebi.ac.uk/pdbsum/9nyz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nyz ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NMDZ1_RAT NMDZ1_RAT] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.<ref>PMID:15996549</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Rattus norvegicus]]
+[[Category: Hansen KB]]
+[[Category: Lotti JS]]
+[[Category: McClelland LJ]]
+[[Category: Syrenne JT]]
+[[Category: Yates-Hansen CK]]