9kr9: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9kr9 is ~~ON HOLD~~ ~~until Paper Publication~~

==Overall structure of HKU5 S protein with S468A/Y463A mutation==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9kr9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pipistrellus_bat_coronavirus_HKU5 Pipistrellus bat coronavirus HKU5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KR9 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9KR9 FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8Å</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9kr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9kr9 OCA], [https://pdbe.org/9kr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9kr9 RCSB], [https://www.ebi.ac.uk/pdbsum/9kr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9kr9 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/SPIKE_BCHK5 SPIKE_BCHK5] S1 region attaches the virion to the cell membrane by interacting with cell receptors, initiating the infection. S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes (By similarity).

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Pipistrellus bat coronavirus HKU5]]

[[Category: Xia LY]]

[[Category: Zhang YY]]

[[Category: Zhou Q]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9kr9 is ON HOLD  until Paper Publication
+==Overall structure of HKU5 S protein with S468A/Y463A mutation==
+<StructureSection load='9kr9' size='340' side='right'caption='[[9kr9]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9kr9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pipistrellus_bat_coronavirus_HKU5 Pipistrellus bat coronavirus HKU5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KR9 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9kr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9kr9 OCA], [https://pdbe.org/9kr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9kr9 RCSB], [https://www.ebi.ac.uk/pdbsum/9kr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9kr9 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SPIKE_BCHK5 SPIKE_BCHK5] S1 region attaches the virion to the cell membrane by interacting with cell receptors, initiating the infection.  S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Pipistrellus bat coronavirus HKU5]]
+[[Category: Xia LY]]
+[[Category: Zhang YY]]
+[[Category: Zhou Q]]