9n88: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9n88 is ~~ON HOLD until Paper Publication~~

==PROTAC-induced IRE1 ternary complex==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9n88]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9N88 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9N88 FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.6Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BWF:(2~{S},4~{R})-1-[(2~{S})-3,3-dimethyl-2-[5-[4-[4-[(7-oxidanylidene-8-propan-2-yl-pyrido[2,3-d]pyrimidin-2-yl)amino]cyclohexyl]piperazin-1-yl]pentanoylamino]butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide'>A1BWF</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9n88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9n88 OCA], [https://pdbe.org/9n88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9n88 RCSB], [https://www.ebi.ac.uk/pdbsum/9n88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9n88 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/ERN1_HUMAN ERN1_HUMAN] Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.<ref>PMID:9637683</ref> <ref>PMID:11175748</ref> <ref>PMID:12637535</ref> [UniProtKB:Q9EQY0]

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Ashkenazi A]]

[[Category: Azumaya C]]

[[Category: Du J]]

[[Category: Hsu PL]]

[[Category: Johnson M]]

[[Category: Rohou A]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9n88 is ON HOLD  until Paper Publication
+==PROTAC-induced IRE1 ternary complex==
+<StructureSection load='9n88' size='340' side='right'caption='[[9n88]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9n88]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9N88 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9N88 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BWF:(2~{S},4~{R})-1-[(2~{S})-3,3-dimethyl-2-[5-[4-[4-[(7-oxidanylidene-8-propan-2-yl-pyrido[2,3-d]pyrimidin-2-yl)amino]cyclohexyl]piperazin-1-yl]pentanoylamino]butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide'>A1BWF</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9n88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9n88 OCA], [https://pdbe.org/9n88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9n88 RCSB], [https://www.ebi.ac.uk/pdbsum/9n88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9n88 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ERN1_HUMAN ERN1_HUMAN] Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.<ref>PMID:9637683</ref> <ref>PMID:11175748</ref> <ref>PMID:12637535</ref> [UniProtKB:Q9EQY0]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Ashkenazi A]]
+[[Category: Azumaya C]]
+[[Category: Du J]]
+[[Category: Hsu PL]]
+[[Category: Johnson M]]
+[[Category: Rohou A]]