9riu: Difference between revisions
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==Co-crystal of broadly neutralizing VHH in complex with short neurotoxin 1 (P01426) Naja pallida== | |||
<StructureSection load='9riu' size='340' side='right'caption='[[9riu]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9riu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_pallida Naja pallida] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RIU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RIU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9riu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9riu OCA], [https://pdbe.org/9riu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9riu RCSB], [https://www.ebi.ac.uk/pdbsum/9riu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9riu ProSAT]</span></td></tr> | ||
[[Category: Laustsen | </table> | ||
[[Category: | == Function == | ||
[https://www.uniprot.org/uniprot/3S11_NAJPA 3S11_NAJPA] Binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs) (tested on Torpedo marmorata AChR, Kd=0.07 nM) and with low affinity to neuronal alpha-7/CHRNA7 nAChRs (tested on chimeric receptor, Kd=3 uM) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission (PubMed:9305882). Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site.<ref>PMID:9305882</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Naja pallida]] | |||
[[Category: Vicugna pacos]] | |||
[[Category: Burlet NJ]] | |||
[[Category: Laustsen AH]] | |||
[[Category: Morth JP]] | |||
Latest revision as of 09:41, 6 November 2025
Co-crystal of broadly neutralizing VHH in complex with short neurotoxin 1 (P01426) Naja pallida
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