9efj: Difference between revisions
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==Irreversible Mcl-1/HIT2 Complex== | |||
<StructureSection load='9efj' size='340' side='right'caption='[[9efj]], [[Resolution|resolution]] 1.82Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9efj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EFJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EFJ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BI3:5-{[(1R)-2,3-dihydro-1H-indene-1-carbonyl]amino}pyridin-3-yl+hydrogen+sulfate'>A1BI3</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9efj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9efj OCA], [https://pdbe.org/9efj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9efj RCSB], [https://www.ebi.ac.uk/pdbsum/9efj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9efj ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> | ||
[[Category: Prentiss | == References == | ||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Assar Z]] | |||
[[Category: Baggio C]] | |||
[[Category: Muzzarelli KM]] | |||
[[Category: Pellecchia M]] | |||
[[Category: Prentiss AM]] | |||
[[Category: Udompholkul P]] | |||
