9hbm: Difference between revisions
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==Crystal structure of human NUDT14 in complex with a potent inhibitor (MA-955-10)== | |||
<StructureSection load='9hbm' size='340' side='right'caption='[[9hbm]], [[Resolution|resolution]] 1.83Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9hbm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HBM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HBM FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1ITN:1-(1-methylpiperidin-4-yl)-3-(4-propan-2-yloxyphenyl)pyrazolo[3,4-d]pyrimidin-4-amine'>A1ITN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hbm OCA], [https://pdbe.org/9hbm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hbm RCSB], [https://www.ebi.ac.uk/pdbsum/9hbm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hbm ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NUD14_HUMAN NUD14_HUMAN] Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Adcock C]] | |||
[[Category: Apostolidou M]] | |||
[[Category: Balikci E]] | |||
[[Category: Feyerherm C]] | |||
[[Category: Huber K]] | |||
[[Category: McGown A]] | |||
[[Category: Spencer J]] | |||
Latest revision as of 07:30, 19 November 2025
Crystal structure of human NUDT14 in complex with a potent inhibitor (MA-955-10)
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