9qpf: Difference between revisions
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==Solution structure of Sox2 DBD== | |||
<StructureSection load='9qpf' size='340' side='right'caption='[[9qpf]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9qpf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QPF FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qpf OCA], [https://pdbe.org/9qpf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qpf RCSB], [https://www.ebi.ac.uk/pdbsum/9qpf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qpf ProSAT]</span></td></tr> | ||
[[Category: Orsetti | </table> | ||
[[Category: Van Ingen | == Disease == | ||
[https://www.uniprot.org/uniprot/SOX2_HUMAN SOX2_HUMAN] Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:[https://omim.org/entry/206900 206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.<ref>PMID:12612584</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SOX2_HUMAN SOX2_HUMAN] Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).<ref>PMID:18035408</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Orsetti A]] | |||
[[Category: Van Ingen H]] | |||
Latest revision as of 07:48, 19 November 2025
Solution structure of Sox2 DBD
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