Sandbox: Difference between revisions

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 ===Background===
-The electrically conductive nanowires that extend from cells of ''Geobacter sulfurreducens'' have long been thought to be pili assembled from PilA protein. However, the evidence was indirect. Here, the structure of filaments of wild type ''Geobacter sulfurreducens'', confirmed to be electrically conductive, was determined by [[cryo-electron microscopy]] ([[6ef8]])<ref name="m3">PMID:30951668</ref>. Surprisingly, these nanowires are assembled from outer membrane cytochrome OmcS. These findings were confirmed a short time later ([[6nef]])<ref name="strauss">PMID:31925024</ref> by a group expressing alternative interpretations<ref>PMID:31608018</ref>.
+The organic anion transporter 1 (OAT1) plays a key role in excreting waste from organic drug metabolism and
+contributes significantly to drug-drug interactions and drug disposition. However, the structural basis of specific
+substrate and inhibitor transport by human OAT1 (hOAT1) has remained elusive. Here are four
+cryogenic electron microscopy [[(cryo-EM)]] structures of hOAT1 in its inward-facing conformation: the apo
+form, the substrate (olmesartan)-bound form with different anions, and the inhibitor (probenecid)-bound
+form.
 ===Nanowire Structure===

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