Sandbox: Difference between revisions
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::*Exhibits pseudo-two-fold symmetry, divided into an N-lobe (TMs 1-6) and a C-lobe (TMs 7-12). | ::*Exhibits pseudo-two-fold symmetry, divided into an N-lobe (TMs 1-6) and a C-lobe (TMs 7-12). | ||
# | # Two'''Central Binding Cavity:''' | ||
::*The cavity is located between the N-lobe (formed by TM1, TM2, TM4, TM5) and the C-lobe (formed by TM7, TM8, TM10, TM11). | ::*The cavity is located between the N-lobe (formed by TM1, TM2, TM4, TM5) and the C-lobe (formed by TM7, TM8, TM10, TM11). | ||
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::*The cavity is lined by 29 residues, forming a hydrophobic and aromatic-rich environment. | ::*The cavity is lined by 29 residues, forming a hydrophobic and aromatic-rich environment. | ||
# | # Three'''Cavity Borders and Cytosolic Gate:''' | ||
::*The top border (extracellular side) of the cavity is formed by residues including N35, Y230, Y353, and Y354. | ::*The top border (extracellular side) of the cavity is formed by residues including N35, Y230, Y353, and Y354. | ||
