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of organic anion drugs from the blood into kidney epithelial | of organic anion drugs from the blood into kidney epithelial | ||
cells by utilizing the α-ketoglutarate (α-KG) gradient across the | cells by utilizing the α-ketoglutarate (α-KG) gradient across the | ||
membrane established by the tricarboxylic acid (TCA) cycle.The organic anion transporter 1 (OAT1) also plays a key role in excreting waste from organic drug metabolism and | membrane established by the tricarboxylic acid (TCA) cycle.<ref>Ingraham, L., Li, M., Renfro, J.L., Parker, S., Vapurcuyan, A., Hanna, I., and | ||
Pelis, R.M. (2014). A plasma concentration of α-ketoglutarate influences | |||
the kinetic interaction of ligands with organic anion transporter 1. Mol. | |||
Pharmacol. 86, 86–95. https://doi.org/10.1124/mol.114.091777.</ref>The organic anion transporter 1 (OAT1) also plays a key role in excreting waste from organic drug metabolism and | |||
contributes significantly to drug-drug interactions and drug disposition. However, the structural basis of specific | contributes significantly to drug-drug interactions and drug disposition. However, the structural basis of specific | ||
substrate and inhibitor transport by human OAT1 (hOAT1) has remained elusive. Here are four | substrate and inhibitor transport by human OAT1 (hOAT1) has remained elusive. Here are four | ||
