HOAT1: Difference between revisions
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Pelis, R.M. (2014). A plasma concentration of α-ketoglutarate influences | Pelis, R.M. (2014). A plasma concentration of α-ketoglutarate influences | ||
the kinetic interaction of ligands with organic anion transporter 1. Mol. | the kinetic interaction of ligands with organic anion transporter 1. Mol. | ||
Pharmacol. 86, 86–95. https://doi.org/10.1124/mol.114.091777.</ref>OAT1 also plays a key role in excreting waste from organic drug metabolism and | Pharmacol. 86, 86–95. https://doi.org/10.1124/mol.114.091777.</ref> <ref>Uwai, Y., Kawasaki, T., and Nabekura, T. (2017). D-Malate decreases renal | ||
content of α-ketoglutarate, a driving force of organic anion transporters | |||
OAT1 and OAT3, resulting in inhibited tubular secretion of phenolsulfonphthalein, | |||
in rats. Biopharm. Drug Dispos. 38, 479–485. https://doi.org/10. | |||
1002/bdd.2089.</ref>OAT1 also plays a key role in excreting waste from organic drug metabolism and | |||
contributes significantly to drug-drug interactions and drug disposition. However, the structural basis of specific | contributes significantly to drug-drug interactions and drug disposition. However, the structural basis of specific | ||
substrate and inhibitor transport by human OAT1 (hOAT1) has remained elusive. Here are four | substrate and inhibitor transport by human OAT1 (hOAT1) has remained elusive. Here are four | ||
