9kvi: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9kvi is ~~ON HOLD until Paper Publication~~

==A Cryo_EM structure of 5_HT1A complex with DMT==

~~Authors~~: ~~Yuan~~, Q., Li, S.

== Structural highlights ==

<table><tr><td colspan='2'>[[9kvi]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KVI OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9KVI FirstGlance].

~~Description~~: ~~A Cryo_EM structure~~ of ~~5_HT1A complex~~ with ~~DMT~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.54Å</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EG8:3-[2-(dimethylamino)ethyl]-1~{H}-indol-5-ol'>A1EG8</scene>, <scene name='pdbligand=CHO:GLYCOCHENODEOXYCHOLIC+ACID'>CHO</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=J40:[(2~{R})-1-[oxidanyl-[(2~{R},3~{R},5~{S},6~{R})-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl]+(5~{E},8~{E})-hexadeca-5,8,11,14-tetraenoate'>J40</scene></td></tr>

[[Category: ~~Yuan, Q~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9kvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9kvi OCA], [https://pdbe.org/9kvi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9kvi RCSB], [https://www.ebi.ac.uk/pdbsum/9kvi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9kvi ProSAT]</td></tr>

[[Category: Li, S]]

</table>

== Function ==

[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Li S]]

[[Category: Yuan Q]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9kvi is ON HOLD  until Paper Publication
+==A Cryo_EM structure of 5_HT1A complex with DMT==
+<StructureSection load='9kvi' size='340' side='right'caption='[[9kvi]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
-Authors: Yuan, Q., Li, S.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9kvi]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KVI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KVI FirstGlance]. <br>
-Description: A Cryo_EM structure of 5_HT1A complex with DMT
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.54&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EG8:3-[2-(dimethylamino)ethyl]-1~{H}-indol-5-ol'>A1EG8</scene>, <scene name='pdbligand=CHO:GLYCOCHENODEOXYCHOLIC+ACID'>CHO</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=J40:[(2~{R})-1-[oxidanyl-[(2~{R},3~{R},5~{S},6~{R})-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl]+(5~{E},8~{E})-hexadeca-5,8,11,14-tetraenoate'>J40</scene></td></tr>
-[[Category: Yuan, Q]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9kvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9kvi OCA], [https://pdbe.org/9kvi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9kvi RCSB], [https://www.ebi.ac.uk/pdbsum/9kvi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9kvi ProSAT]</span></td></tr>
-[[Category: Li, S]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Li S]]
+[[Category: Yuan Q]]