9v6j: Difference between revisions
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==Structure-Guided Design of Picomolar-level Macrocyclic TRPC5 Channel Inhibitors with Antidepressant Activity== | |||
<StructureSection load='9v6j' size='340' side='right'caption='[[9v6j]], [[Resolution|resolution]] 3.23Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9v6j]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9V6J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9V6J FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.23Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[Category: Che | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9v6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9v6j OCA], [https://pdbe.org/9v6j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9v6j RCSB], [https://www.ebi.ac.uk/pdbsum/9v6j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9v6j ProSAT]</span></td></tr> | ||
[[Category: Cheng | </table> | ||
[[Category: Xiong | == Function == | ||
[[Category: Zhang | [https://www.uniprot.org/uniprot/TRPC5_MOUSE TRPC5_MOUSE] Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion. | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Che T]] | |||
[[Category: Cheng XY]] | |||
[[Category: Xiong B]] | |||
[[Category: Zhang J]] | |||
Latest revision as of 19:41, 4 December 2025
Structure-Guided Design of Picomolar-level Macrocyclic TRPC5 Channel Inhibitors with Antidepressant Activity
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