9ngj: Difference between revisions

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'''Unreleased structure'''


The entry 9ngj is ON HOLD  until Paper Publication
==CryoEM structure of human ABCD3 bound to Phytanoyl-CoA==
 
<StructureSection load='9ngj' size='340' side='right'caption='[[9ngj]], [[Resolution|resolution]] 3.13&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9ngj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NGJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NGJ FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.13&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CAN:S-{(3R,5S,9S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5,10,14-tetraoxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl}+(3S,7R,11R)-3,7,11,15-tetramethylhexadecanethioate+(non-preferred+name)'>A1CAN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ngj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ngj OCA], [https://pdbe.org/9ngj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ngj RCSB], [https://www.ebi.ac.uk/pdbsum/9ngj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ngj ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ABCD3_HUMAN ABCD3_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/ABCD3_HUMAN ABCD3_HUMAN] Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation (PubMed:11248239, PubMed:24333844, PubMed:25168382, PubMed:29397936). Has fatty acyl-CoA thioesterase and ATPase activities (PubMed:29397936). Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes (By similarity). Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:24333844, PubMed:25944712).[UniProtKB:P33897]<ref>PMID:11248239</ref> <ref>PMID:24333844</ref> <ref>PMID:25168382</ref> <ref>PMID:25944712</ref> <ref>PMID:29397936</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Gupta M]]
[[Category: Khandelwal NK]]
[[Category: Stroud RM]]
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