9hq0: Difference between revisions
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==SARM1 TIR domain in complex with compound 7-ADPR== | |||
<StructureSection load='9hq0' size='340' side='right'caption='[[9hq0]], [[Resolution|resolution]] 2.13Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9hq0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HQ0 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IW3:[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+[(2~{R},3~{S},4~{R},5~{R})-5-[4-[(1~{S})-1-[[(3~{R})-4,4-bis(fluoranyl)oxolan-3-yl]carbamoyl-methyl-amino]ethyl]pyridin-1-ium-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl+hydrogen+phosphate'>A1IW3</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hq0 OCA], [https://pdbe.org/9hq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hq0 RCSB], [https://www.ebi.ac.uk/pdbsum/9hq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hq0 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SARM1_HUMAN SARM1_HUMAN] Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.<ref>PMID:15123841</ref> <ref>PMID:16964262</ref> <ref>PMID:16985498</ref> <ref>PMID:20306472</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Aregger N]] | |||
[[Category: Benz J]] | |||
[[Category: Bilyard M]] | |||
[[Category: Bonardi C]] | |||
[[Category: Brigo A]] | |||
[[Category: Burger D]] | |||
[[Category: Caramenti P]] | |||
[[Category: Gasser C]] | |||
[[Category: Giroud M]] | |||
[[Category: Grether U]] | |||
[[Category: Haap W]] | |||
[[Category: Haider A]] | |||
[[Category: Hilbert M]] | |||
[[Category: Kalayil S]] | |||
[[Category: Keaney J]] | |||
[[Category: Kuhn B]] | |||
[[Category: Malnight-Alvarez A]] | |||
[[Category: Mani A]] | |||
[[Category: Mendel M]] | |||
[[Category: Pinard E]] | |||
[[Category: Plitzko I]] | |||
[[Category: Ritter M]] | |||
[[Category: Rombach D]] | |||
[[Category: Saal W]] | |||
[[Category: Schmid P]] | |||
[[Category: Sechet N]] | |||
[[Category: Steiner S]] | |||
[[Category: Topp A]] | |||
[[Category: Westwood P]] | |||
[[Category: Wittwer M]] | |||
[[Category: Zambaldo C]] | |||
Latest revision as of 05:12, 24 December 2025
SARM1 TIR domain in complex with compound 7-ADPR
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