9hqf: Difference between revisions

Latest revision as of 05:13, 24 December 2025

SARM1 TIR domain in complex with compound 7-ADPR

Structural highlights

9hqf is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.73Å
Ligands:	A1IWL
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SARM1_HUMAN Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.^[1] ^[2] ^[3] ^[4]

References

↑ Liberati NT, Fitzgerald KA, Kim DH, Feinbaum R, Golenbock DT, Ausubel FM. Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6593-8. PMID:15123841 doi:https://dx.doi.org/10.1073/pnas.0308625101
↑ Carty M, Goodbody R, Schroder M, Stack J, Moynagh PN, Bowie AG. The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. Nat Immunol. 2006 Oct;7(10):1074-81. doi: 10.1038/ni1382. Epub 2006 Sep 10. PMID:16964262 doi:https://dx.doi.org/10.1038/ni1382
↑ O'Neill LA. DisSARMing Toll-like receptor signaling. Nat Immunol. 2006 Oct;7(10):1023-5. doi: 10.1038/ni1006-1023. PMID:16985498 doi:https://dx.doi.org/10.1038/ni1006-1023
↑ Peng J, Yuan Q, Lin B, Panneerselvam P, Wang X, Luan XL, Lim SK, Leung BP, Ho B, Ding JL. SARM inhibits both TRIF- and MyD88-mediated AP-1 activation. Eur J Immunol. 2010 Jun;40(6):1738-47. doi: 10.1002/eji.200940034. PMID:20306472 doi:https://dx.doi.org/10.1002/eji.200940034

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Liberati NT, Fitzgerald KA, Kim DH, Feinbaum R, Golenbock DT, Ausubel FM. Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6593-8. PMID:15123841 doi:https://dx.doi.org/10.1073/pnas.0308625101

[2] Carty M, Goodbody R, Schroder M, Stack J, Moynagh PN, Bowie AG. The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. Nat Immunol. 2006 Oct;7(10):1074-81. doi: 10.1038/ni1382. Epub 2006 Sep 10. PMID:16964262 doi:https://dx.doi.org/10.1038/ni1382

[3] O'Neill LA. DisSARMing Toll-like receptor signaling. Nat Immunol. 2006 Oct;7(10):1023-5. doi: 10.1038/ni1006-1023. PMID:16985498 doi:https://dx.doi.org/10.1038/ni1006-1023

[4] Peng J, Yuan Q, Lin B, Panneerselvam P, Wang X, Luan XL, Lim SK, Leung BP, Ho B, Ding JL. SARM inhibits both TRIF- and MyD88-mediated AP-1 activation. Eur J Immunol. 2010 Jun;40(6):1738-47. doi: 10.1002/eji.200940034. PMID:20306472 doi:https://dx.doi.org/10.1002/eji.200940034

[1]

[2]

[3]

[4]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9hqf is ON HOLD  until Paper Publication
+==SARM1 TIR domain in complex with compound 7-ADPR==
+<StructureSection load='9hqf' size='340' side='right'caption='[[9hqf]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
-Authors: Giroud, M., Kuhn, B., Steiner, S., Westwood, P., Mendel, M., Mani, A., Pinard, E., Haap, W., Grether, U., Caramenti, P., Rombach, D., Zambaldo, C., Ritter, M., Schmid, P., Gasser, C., Aregger, N., Sechet, N., Topp, A., Bilyard, M., Malnight-Alvarez, A., Plitzko, I., Hilbert, M., Kalayil, S., Burger, D., Bonardi, C., Saal, W., Haider, A., Wittwer, M., Brigo, A., Keaney, J., Benz, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9hqf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HQF FirstGlance]. <br>
-Description: SARM1 TIR domain in complex with compound 7-ADPR
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IWL:[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+[(2~{R},3~{S},4~{R},5~{R})-5-[(5~{S})-5-[[(3~{R})-4,4-bis(fluoranyl)oxolan-3-yl]carbamoyl-methyl-amino]-2,3,4,5-tetrahydrooxepino[2,3-c]pyridin-8-ium-8-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl+hydrogen+phosphate'>A1IWL</scene></td></tr>
-[[Category: Keaney, J]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hqf OCA], [https://pdbe.org/9hqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hqf RCSB], [https://www.ebi.ac.uk/pdbsum/9hqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hqf ProSAT]</span></td></tr>
-[[Category: Bilyard, M]]
+</table>
-[[Category: Plitzko, I]]
+== Function ==
-[[Category: Kalayil, S]]
+[https://www.uniprot.org/uniprot/SARM1_HUMAN SARM1_HUMAN] Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.<ref>PMID:15123841</ref> <ref>PMID:16964262</ref> <ref>PMID:16985498</ref> <ref>PMID:20306472</ref>
-[[Category: Giroud, M]]
+== References ==
-[[Category: Rombach, D]]
+<references/>
-[[Category: Wittwer, M]]
+__TOC__
-[[Category: Hilbert, M]]
+</StructureSection>
-[[Category: Brigo, A]]
+[[Category: Homo sapiens]]
-[[Category: Saal, W]]
+[[Category: Large Structures]]
-[[Category: Zambaldo, C]]
+[[Category: Aregger N]]
-[[Category: Sechet, N]]
+[[Category: Benz J]]
-[[Category: Pinard, E]]
+[[Category: Bilyard M]]
-[[Category: Mendel, M]]
+[[Category: Bonardi C]]
-[[Category: Grether, U]]
+[[Category: Brigo A]]
-[[Category: Haider, A]]
+[[Category: Burger D]]
-[[Category: Ritter, M]]
+[[Category: Caramenti P]]
-[[Category: Aregger, N]]
+[[Category: Gasser C]]
-[[Category: Burger, D]]
+[[Category: Giroud M]]
-[[Category: Haap, W]]
+[[Category: Grether U]]
-[[Category: Bonardi, C]]
+[[Category: Haap W]]
-[[Category: Kuhn, B]]
+[[Category: Haider A]]
-[[Category: Gasser, C]]
+[[Category: Hilbert M]]
-[[Category: Topp, A]]
+[[Category: Kalayil S]]
-[[Category: Westwood, P]]
+[[Category: Keaney J]]
-[[Category: Schmid, P]]
+[[Category: Kuhn B]]
-[[Category: Caramenti, P]]
+[[Category: Malnight-Alvarez A]]
-[[Category: Steiner, S]]
+[[Category: Mani A]]
-[[Category: Mani, A]]
+[[Category: Mendel M]]
-[[Category: Benz, J]]
+[[Category: Pinard E]]
-[[Category: Malnight-Alvarez, A]]
+[[Category: Plitzko I]]
+[[Category: Ritter M]]
+[[Category: Rombach D]]
+[[Category: Saal W]]
+[[Category: Schmid P]]
+[[Category: Sechet N]]
+[[Category: Steiner S]]
+[[Category: Topp A]]
+[[Category: Westwood P]]
+[[Category: Wittwer M]]
+[[Category: Zambaldo C]]

9hqf: Difference between revisions

Latest revision as of 05:13, 24 December 2025

SARM1 TIR domain in complex with compound 7-ADPR

Structural highlights

Function

References

Contents

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