9frs: Difference between revisions
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==Human PARP10 ART domain bound to a phthalazinone-based inhibitor== | |||
<StructureSection load='9frs' size='340' side='right'caption='[[9frs]], [[Resolution|resolution]] 2.02Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9frs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9FRS FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.02Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IFC:4-[[4-fluoranyl-3-[[(5~{R})-5-methyl-3-(1,3-thiazol-2-yl)-6,8-dihydro-5~{H}-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]carbonyl]phenyl]methyl]-2~{H}-phthalazin-1-one'>A1IFC</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
[[Category: Cohen | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9frs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9frs OCA], [https://pdbe.org/9frs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9frs RCSB], [https://www.ebi.ac.uk/pdbsum/9frs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9frs ProSAT]</span></td></tr> | ||
[[Category: Moche | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/PAR10_HUMAN PAR10_HUMAN] May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.<ref>PMID:15674325</ref> <ref>PMID:16455663</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Cohen MS]] | |||
[[Category: Moche M]] | |||
[[Category: Schuler H]] | |||
[[Category: Upadhyaya K]] | |||
Latest revision as of 08:33, 14 January 2026
Human PARP10 ART domain bound to a phthalazinone-based inhibitor
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