9lb2: Difference between revisions

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'''Unreleased structure'''


The entry 9lb2 is ON HOLD  until Paper Publication
==E2s domain of HEV ORF2 type 4==
 
<StructureSection load='9lb2' size='340' side='right'caption='[[9lb2]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
Authors: Zimin, T., Guiping, W., Hai, Y., Qing, Z., Zizheng, Z., Ningshao, X., Shaowei, L.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9lb2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_E_virus_(strain_Burma) Hepatitis E virus (strain Burma)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9LB2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9LB2 FirstGlance]. <br>
Description: E2s domain of HEV ORF2 type 4
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BU3:(R,R)-2,3-BUTANEDIOL'>BU3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Ningshao, X]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9lb2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9lb2 OCA], [https://pdbe.org/9lb2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9lb2 RCSB], [https://www.ebi.ac.uk/pdbsum/9lb2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9lb2 ProSAT]</span></td></tr>
[[Category: Zizheng, Z]]
</table>
[[Category: Hai, Y]]
== Function ==
[[Category: Shaowei, L]]
[https://www.uniprot.org/uniprot/CAPSD_HEVBU CAPSD_HEVBU] Plays a role in the inhibition of host antibody-mediated neutralization without blocking viral cell entry.[UniProtKB:Q9YLQ9]  Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter. The capsid is composed of 60 copies linked to each other. Binds to the 5' end of the genomic RNA to mediate genome encapsidation (PubMed:14671114, PubMed:15557331). Binds to heparin surface proteoglycans (HSPGs) to mediate viral entry (By similarity). Additionally, the interactions with host ASGR1 and ASGR2 facilitate viral infection of hepatocytes (By similarity). Inhibits IFN production by blocking host TBK1-induced IRF3 phosphorylation (By similarity). The nuclear form probably modulates host gene expression (By similarity).[UniProtKB:P33426][UniProtKB:Q81871]<ref>PMID:14671114</ref> <ref>PMID:15557331</ref>
[[Category: Qing, Z]]
== References ==
[[Category: Guiping, W]]
<references/>
[[Category: Zimin, T]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Guiping W]]
[[Category: Hai Y]]
[[Category: Ningshao X]]
[[Category: Qing Z]]
[[Category: Shaowei L]]
[[Category: Zimin T]]
[[Category: Zizheng Z]]
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