9ft4: Difference between revisions

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~~'''Unreleased structure'''~~

~~The~~ entry ~~9ft4~~ is ~~ON HOLD until Paper Publication~~

==Crystal structure of human DYRK1A in complex with ARN25507==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9ft4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FT4 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9FT4 FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IFJ:~{N}4-(5-cyclopropyl-1~{H}-pyrazol-3-yl)-~{N}2-(phenylmethyl)furo[3,2-d]pyrimidine-2,4-diamine'>A1IFJ</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9ft4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ft4 OCA], [https://pdbe.org/9ft4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ft4 RCSB], [https://www.ebi.ac.uk/pdbsum/9ft4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ft4 ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN] Defects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:[https://omim.org/entry/614104 614104]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:21294719</ref>

== Function ==

[https://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN] May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.<ref>PMID:8769099</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Balboni B]]

[[Category: Cavalli A]]

[[Category: Dalle Vedove A]]

[[Category: Demuro S]]

[[Category: Di Martino RMC]]

[[Category: Girotto S]]

[[Category: Storici P]]

[[Category: Tripathi SK]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9ft4 is ON HOLD  until Paper Publication
+==Crystal structure of human DYRK1A in complex with ARN25507==
+<StructureSection load='9ft4' size='340' side='right'caption='[[9ft4]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9ft4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9FT4 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IFJ:~{N}4-(5-cyclopropyl-1~{H}-pyrazol-3-yl)-~{N}2-(phenylmethyl)furo[3,2-d]pyrimidine-2,4-diamine'>A1IFJ</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ft4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ft4 OCA], [https://pdbe.org/9ft4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ft4 RCSB], [https://www.ebi.ac.uk/pdbsum/9ft4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ft4 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN] Defects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:[https://omim.org/entry/614104 614104]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:21294719</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN] May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.<ref>PMID:8769099</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Balboni B]]
+[[Category: Cavalli A]]
+[[Category: Dalle Vedove A]]
+[[Category: Demuro S]]
+[[Category: Di Martino RMC]]
+[[Category: Girotto S]]
+[[Category: Storici P]]
+[[Category: Tripathi SK]]