9lb5: Difference between revisions
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==mutant S483T/G490N/V492M/S497T/A599G of HEV-1 E2s domain== | |||
<StructureSection load='9lb5' size='340' side='right'caption='[[9lb5]], [[Resolution|resolution]] 1.35Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9lb5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia Escherichia] and [https://en.wikipedia.org/wiki/Hepatitis_E_virus_(strain_Burma) Hepatitis E virus (strain Burma)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9LB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9LB5 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
[[Category: Guiping | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9lb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9lb5 OCA], [https://pdbe.org/9lb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9lb5 RCSB], [https://www.ebi.ac.uk/pdbsum/9lb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9lb5 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/CAPSD_HEVBU CAPSD_HEVBU] Plays a role in the inhibition of host antibody-mediated neutralization without blocking viral cell entry.[UniProtKB:Q9YLQ9] Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter. The capsid is composed of 60 copies linked to each other. Binds to the 5' end of the genomic RNA to mediate genome encapsidation (PubMed:14671114, PubMed:15557331). Binds to heparin surface proteoglycans (HSPGs) to mediate viral entry (By similarity). Additionally, the interactions with host ASGR1 and ASGR2 facilitate viral infection of hepatocytes (By similarity). Inhibits IFN production by blocking host TBK1-induced IRF3 phosphorylation (By similarity). The nuclear form probably modulates host gene expression (By similarity).[UniProtKB:P33426][UniProtKB:Q81871]<ref>PMID:14671114</ref> <ref>PMID:15557331</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
</StructureSection> | |||
[[Category: Escherichia]] | |||
[[Category: Large Structures]] | |||
[[Category: Guiping W]] | |||
[[Category: Hai Y]] | |||
[[Category: Ningshao X]] | |||
[[Category: Qing Z]] | |||
[[Category: Shaowei L]] | |||
[[Category: Zimin T]] | |||
[[Category: Zizheng Z]] | |||
Latest revision as of 11:06, 10 February 2026
mutant S483T/G490N/V492M/S497T/A599G of HEV-1 E2s domain
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