9e4a: Difference between revisions
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The entry | ==Human ASIC1a at pH 8.5 with domain-swapped transmembrane domain== | ||
<StructureSection load='9e4a' size='340' side='right'caption='[[9e4a]], [[Resolution|resolution]] 2.74Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9e4a]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9E4A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9E4A FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.74Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9e4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9e4a OCA], [https://pdbe.org/9e4a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9e4a RCSB], [https://www.ebi.ac.uk/pdbsum/9e4a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9e4a ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ASIC1_HUMAN ASIC1_HUMAN] Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.<ref>PMID:22760635</ref> Isoform 1 does not display proton-gated cation channel activity.<ref>PMID:22760635</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Baconguis I]] | |||
[[Category: Cahill J]] | |||
[[Category: Hartfield KA]] | |||
Latest revision as of 13:01, 10 February 2026
Human ASIC1a at pH 8.5 with domain-swapped transmembrane domain
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