9grm: Difference between revisions

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'''Unreleased structure'''


The entry 9grm is ON HOLD until Paper Publication
==Cdc42 in complex with inhibitory peptide==
 
<StructureSection load='9grm' size='340' side='right'caption='[[9grm]]' scene=''>
Authors: Mott, H.R., Owen, D., Murphy, N.P.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9grm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GRM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GRM FirstGlance]. <br>
Description: Cdc42 in complex with inhibitory peptide
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, models</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
[[Category: Owen, D]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9grm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9grm OCA], [https://pdbe.org/9grm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9grm RCSB], [https://www.ebi.ac.uk/pdbsum/9grm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9grm ProSAT]</span></td></tr>
[[Category: Murphy, N.P]]
</table>
[[Category: Mott, H.R]]
== Function ==
[https://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Mott HR]]
[[Category: Murphy NP]]
[[Category: Owen D]]
Retrieved from "https://proteopedia.org/9grm"