9zn0: Difference between revisions

Latest revision as of 13:31, 10 February 2026

Crystal structure of the Commd10 S50E HN domain mutant in domain swapped conformation

Structural highlights

9zn0 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.12Å
Ligands:	LEA
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

COMDA_HUMAN Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).^[1] ^[2] ^[3] ^[4]

References

↑ Burstein E, Hoberg JE, Wilkinson AS, Rumble JM, Csomos RA, Komarck CM, Maine GN, Wilkinson JC, Mayo MW, Duckett CS. COMMD proteins, a novel family of structural and functional homologs of MURR1. J Biol Chem. 2005 Jun 10;280(23):22222-32. Epub 2005 Mar 30. PMID:15799966 doi:https://dx.doi.org/10.1074/jbc.M501928200
↑ Healy MD, McNally KE, Butkovič R, Chilton M, Kato K, Sacharz J, McConville C, Moody ERR, Shaw S, Planelles-Herrero VJ, Yadav SKN, Ross J, Borucu U, Palmer CS, Chen KE, Croll TI, Hall RJ, Caruana NJ, Ghai R, Nguyen THD, Heesom KJ, Saitoh S, Berger I, Schaffitzel C, Williams TA, Stroud DA, Derivery E, Collins BM, Cullen PJ. Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome. Cell. 2023 May 11;186(10):2219-2237.e29. PMID:37172566 doi:10.1016/j.cell.2023.04.003
↑ Laulumaa S, Kumpula EP, Huiskonen JT, Varjosalo M. Structure and interactions of the endogenous human Commander complex. Nat Struct Mol Biol. 2024 Jun;31(6):925-938. PMID:38459129 doi:10.1038/s41594-024-01246-1
↑ Mao X, Gluck N, Chen B, Starokadomskyy P, Li H, Maine GN, Burstein E. COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. J Biol Chem. 2011 Sep 16;286(37):32355-65. PMID:21778237 doi:10.1074/jbc.M111.278408

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Burstein E, Hoberg JE, Wilkinson AS, Rumble JM, Csomos RA, Komarck CM, Maine GN, Wilkinson JC, Mayo MW, Duckett CS. COMMD proteins, a novel family of structural and functional homologs of MURR1. J Biol Chem. 2005 Jun 10;280(23):22222-32. Epub 2005 Mar 30. PMID:15799966 doi:https://dx.doi.org/10.1074/jbc.M501928200

[2] Healy MD, McNally KE, Butkovič R, Chilton M, Kato K, Sacharz J, McConville C, Moody ERR, Shaw S, Planelles-Herrero VJ, Yadav SKN, Ross J, Borucu U, Palmer CS, Chen KE, Croll TI, Hall RJ, Caruana NJ, Ghai R, Nguyen THD, Heesom KJ, Saitoh S, Berger I, Schaffitzel C, Williams TA, Stroud DA, Derivery E, Collins BM, Cullen PJ. Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome. Cell. 2023 May 11;186(10):2219-2237.e29. PMID:37172566 doi:10.1016/j.cell.2023.04.003

[3] Laulumaa S, Kumpula EP, Huiskonen JT, Varjosalo M. Structure and interactions of the endogenous human Commander complex. Nat Struct Mol Biol. 2024 Jun;31(6):925-938. PMID:38459129 doi:10.1038/s41594-024-01246-1

[4] Mao X, Gluck N, Chen B, Starokadomskyy P, Li H, Maine GN, Burstein E. COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. J Biol Chem. 2011 Sep 16;286(37):32355-65. PMID:21778237 doi:10.1074/jbc.M111.278408

[1]

[2]

[3]

[4]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9zn0 is ON HOLD
+==Crystal structure of the Commd10 S50E HN domain mutant in domain swapped conformation==
+<StructureSection load='9zn0' size='340' side='right'caption='[[9zn0]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
-Authors: Collins, B.M., Healy, M.D., Liu, M., Hall, R.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9zn0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ZN0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ZN0 FirstGlance]. <br>
-Description: Crystal structure of the Commd10 S50E HN domain mutant in domain swapped conformation
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.12&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LEA:PENTANOIC+ACID'>LEA</scene></td></tr>
-[[Category: Collins, B.M]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9zn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9zn0 OCA], [https://pdbe.org/9zn0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9zn0 RCSB], [https://www.ebi.ac.uk/pdbsum/9zn0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9zn0 ProSAT]</span></td></tr>
-[[Category: Hall, R]]
+</table>
-[[Category: Healy, M.D]]
+== Function ==
-[[Category: Liu, M]]
+[https://www.uniprot.org/uniprot/COMDA_HUMAN COMDA_HUMAN] Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).<ref>PMID:15799966</ref> <ref>PMID:37172566</ref> <ref>PMID:38459129</ref> <ref>PMID:21778237</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Collins BM]]
+[[Category: Hall R]]
+[[Category: Healy MD]]
+[[Category: Liu M]]

9zn0: Difference between revisions

Latest revision as of 13:31, 10 February 2026

Crystal structure of the Commd10 S50E HN domain mutant in domain swapped conformation

Structural highlights

Function

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools