9ivj: Difference between revisions
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The entry | ==Cryo-EM structure of EBV gH/gL/gp42 in complex with fab 4G12== | ||
<StructureSection load='9ivj' size='340' side='right'caption='[[9ivj]], [[Resolution|resolution]] 3.15Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9ivj]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_4 Human gammaherpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IVJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9IVJ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.15Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ivj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ivj OCA], [https://pdbe.org/9ivj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ivj RCSB], [https://www.ebi.ac.uk/pdbsum/9ivj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ivj ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GH_EBVG GH_EBVG] The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis. The heterodimer gH/gL targets also host EPHA2 to promote viral entry.[UniProtKB:P03231][HAMAP-Rule:MF_04033] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Human gammaherpesvirus 4]] | |||
[[Category: Large Structures]] | |||
[[Category: Fang XY]] | |||
[[Category: Liu Z]] | |||
[[Category: Zeng MS]] | |||
[[Category: Zhao GX]] | |||
Latest revision as of 14:29, 10 February 2026
Cryo-EM structure of EBV gH/gL/gp42 in complex with fab 4G12
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