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'''Unreleased structure'''


The entry 9nmt is ON HOLD  until Paper Publication
==ML418 bound inwardly rectifying potassium channel Kir7.1 R162Q mutant==
 
<StructureSection load='9nmt' size='340' side='right'caption='[[9nmt]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
Authors: Peisley, A., Su, M., Cone, R.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9nmt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NMT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NMT FirstGlance]. <br>
Description: ML418 bound inwardly rectifying potassium channel Kir7.1 R162Q mutant
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BY7:propan-2-yl+{1-[(5-chloro-8-hydroxyquinolin-7-yl)methyl]piperidin-4-yl}carbamate'>A1BY7</scene></td></tr>
[[Category: Su, M]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nmt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nmt OCA], [https://pdbe.org/9nmt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nmt RCSB], [https://www.ebi.ac.uk/pdbsum/9nmt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nmt ProSAT]</span></td></tr>
[[Category: Cone, R]]
</table>
[[Category: Peisley, A]]
== Disease ==
[https://www.uniprot.org/uniprot/KCJ13_HUMAN KCJ13_HUMAN] Leber congenital amaurosis;Snowflake vitreoretinal degeneration. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/KCJ13_HUMAN KCJ13_HUMAN] Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.<ref>PMID:9620703</ref> <ref>PMID:9738472</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cone R]]
[[Category: Peisley A]]
[[Category: Su M]]
Retrieved from "https://proteopedia.org/9nmt"